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(+)-Bicuculline CAS:485-49-4

2017-05-16

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(+)-Bicuculline CAS:485-49-4

Product Name:(+)-Bicuculline

CAS No.:485-49-4

Synonyms:D-Bicuculline

Chemical Name:[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Structure:485-49-4.gif

Purity:99%HPLC

Molecular Formula:C20H17NO6

Molecular Weight:367.36

Appearance:White soild

Solubility:Soluble in DMSO

Biological Activity:

Antagonist of the GABAA receptor, (+)-Bicuculline is an antagonist of the GABAA receptor. (+)-Bicuculline is the parent compound of the water soluble N-methyl derivatives (-)-Bicuculline methiodide and (-)-Bicuculline methobromide. Antagonism of the GABAA receptor by (+)-Bicuculline blocks the neurotransmission inhibition function of the GABA system in vitro.

References:

1. Bormann J The 'ABC' of GABA receptors.Trends Pharmacol Sci 21:16-9 (2000)

2. Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222. PMID: 4393081.

3. Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. PMID: 1247886.

4. Piredda et al (1985) Intracerebral site of convulsant action of bicuculline. Life Sci. 36 1295. PMID:3982215.

5. Sieghart et al (1989) Multiplicity of GABAA-benzodiazepine receptors. TiPS 10 407. PMID: 2559519.