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Resatorvid (TAK-242; CLI-095)

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Catalog No:CL1002 CAS No.:243984-11-4 MDLNo: Formula:C15H17ClFNO4S MW:361.82
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Product Overview
Product Name Resatorvid (TAK-242; CLI-095)
AppearanceOff-white to yellow solid
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Product details

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.

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