Product Name | Y-27632 Dihydrochloride | Y-27632 2HCl |
---|---|
CAS | 129830-38-2 |
Formula | C14H21N3O.2HCl |
MW | 320.26 | 247.34(free) |
Appearance | White to off-white powder |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
5 mg | In-stock | $236.00 | Visible after login | |
10 mg | In-stock | $336.00 | Visible after login | |
25 mg | In-stock | $466.00 | Visible after login | |
50 mg | In-stock | $800.00 | Visible after login |
Product Name | Y-27632 Dihydrochloride | Y-27632 2HCl |
---|---|
CAS | 129830-38-2 |
Formula | C14H21N3O.2HCl |
MW | 320.26 | 247.34(free) |
Appearance | White to off-white powder |
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.