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Y-27632 Dihydrochloride; Y-27632 2HCl

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Catalog No:CL1003 CAS No.:129830-38-2 MDLNo: Formula:C14H21N3O.2HCl MW:320.26
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Product Overview
Product Name Y-27632 Dihydrochloride; Y-27632 2HCl
AppearanceWhite to off-white solid powder
Product details

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. 

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