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RepSox (E-616452; SJN 2511;ALK5 Inhibitor II)

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Catalog No：CL1007 CAS No.：446859-33-2 MDLNo： Formula：C17H13N5 MW： 287.32

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$180.00	Visible after login	- +
10 mg	In-stock	$280.00	Visible after login	- +
25 mg	In-stock	$500.00	Visible after login	- +
50 mg	In-stock	$800.00	Visible after login	- +

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Product Overview

Product Name	RepSox (E-616452; SJN 2511;ALK5 Inhibitor II)
CAS	446859-33-2
Formula	C17H13N5
MW	287.32
Appearance	Light brown to yellow powder

Product details

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.

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CL1007

RepSox (E-616452; SJN 2511;ALK5 Inhibitor II)

446859-33-2 98+%