Home > Category > Signaling Pathways > Endocrinology & Hormones > Estrogen/progestogen Receptor > 4-Hydroxytamoxifen;(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol

4-Hydroxytamoxifen;(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol

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Catalog No:CL1009 CAS No.:68047-06-3 MDLNo: Formula:C26H29NO2 MW:387.52
Size Availability Price(USD) VIP Price (USD) Quantity
5 mg In-stock $180.00 Visible after login
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10 mg In-stock $300.00 Visible after login
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25 mg In-stock $580.00 Visible after login
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50 mg In-stock $1000.00 Visible after login
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Product Overview
Product Name 4-Hydroxytamoxifen;(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen. It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner. 

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