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Dapagliflozin (BMS-512148)

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Catalog No:CL1127 CAS No.:461432-26-8 MDLNo: Formula:C21H25ClO6 MW:408.87
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Product Overview
Product Name Dapagliflozin (BMS-512148)
CAS461432-26-8
FormulaC21H25ClO6
MW408.87
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Dapagliflozin (formerly known as BMS-512148; trade names Farxiga in the US and Forxiga in the EU) is a potent and selective hSGLT2 (sodium-glucose transport proteins) inhibitor with anti-diabetic activity. It inhibits hSGLT2 with an EC50 of 1.1 nM, and exhibits1200-fold selectivity over hSGLT1.  Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Urine is the means by which blood glucose is expelled when this transporter mechanism is blocked.

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