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Tazemetostat (EPZ-6438; E-7438)

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Catalog No：CL1209 CAS No.：1403254-99-8 MDLNo： Formula：C34H44N4O4 MW：572.74

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Product Overview

Product Name	Tazemetostat (EPZ-6438; E-7438)
CAS	1403254-99-8
Formula	C34H44N4O4
MW	572.74
Appearance	Off-white to light yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Tazemetostat, also known as EPZ-6438 and E7438, is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation.

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CL1209

Tazemetostat (EPZ-6438; E-7438)

1403254-99-8