Omipalisib | GSK2126458 | GSK458

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Omipalisib \| GSK2126458 \| GSK458
CAS	1086062-66-9
Formula	C25H17F2N5O3S
MW	505.50
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy.

Related literature

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.

PMID: 22389471 DOI: 10.1158/1535-7163.MCT-11-0989

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.

PMID: 24900173 PMCID: PMC4007793 DOI: 10.1021/ml900028r

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

PMID: 23899692 PMCID: PMC3800496 DOI: 10.1021/cb400430t

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History

CL1337

Omipalisib | GSK2126458 | GSK458

1086062-66-9 98+%

Omipalisib | GSK2126458 | GSK458

Chemical safety data sheet(MSDS)