Vonoprazan Fumarate | TAK-438| 881681-01-2 |富马酸沃诺拉赞

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Availability

Price(USD)

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Quantity

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Product Overview

Product Name	Vonoprazan Fumarate \| TAK-438
CAS	881681-01-2
Formula	C17H16FN3O2S· C4H4O4
MW	461.46 \| 345.39 (Free)
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture and light

Product details

Vonoprazan Fumarate, also known as TAK438, is a new medicine for treating acid-related diseases with a novel mechanism of action called potassium-competitive acid blockers (P-CABs) which competitively inhibits the binding of potassium ions to H+,K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. TAKECAB provides a strong and sustained acid secretion inhibitory effect.

Related literature

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).

PMID: 22512618 DOI: 10.1021/jm300318t

1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.

PMID: 20624992 DOI: 10.1124/jpet.110.170274

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History

CL1412

Vonoprazan Fumarate | TAK-438

881681-01-2 98+%

Vonoprazan Fumarate | TAK-438

Chemical safety data sheet(MSDS)