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Conglobatin

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Catalog No：CL1460 CAS No.：72263-05-9 MDLNo： Formula：C28H38N2O6 MW：498.61

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$800.00	Visible after login	- +
5 mg	3-5days	$2500.00	Visible after login	- +

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Product Overview

Product Name	Conglobatin
CAS	72263-05-9
Formula	C28H38N2O6
MW	498.61
Appearance	White to grayish white powder
Storage condition	Store at -20°C

Product details

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

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CL1460

Conglobatin

72263-05-9 97%