Product Name | Lenvatinib | E7080 |
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CAS | 417716-92-8 |
Formula | C21H19ClN4O4 |
MW | 426.85 |
Appearance | Off-white to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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Product Name | Lenvatinib | E7080 |
---|---|
CAS | 417716-92-8 |
Formula | C21H19ClN4O4 |
MW | 426.85 |
Appearance | Off-white to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities.