SB-408124 Hydrochloride

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	SB-408124 Hydrochloride
CAS	1431697-90-3
Formula	C19H18F2N4O·HCl
MW	392.83 \| 356.38(free)
Appearance	White to gray powder
Storage condition	4°C, sealed storage, away from moisture

Product details

SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K_is of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor.

Related literature

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.

PMID: 14691055 PMCID: PMC1574197 DOI: 10.1038/sj.bjp.0705610

OX1R ANTAGONIST SB408124 ACTION AND EXTRAHYPOTHALAMIC CRF IN RATS AFTER PSYCHOTRAUMATIC EXPOSURE.

PMID: 31322529

Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension.

PMID: 28667055 PMCID: PMC5814649 DOI: 10.1152/ajpheart.00822.2016

CL2397A

H-89 Dihydrochloride | H 89 2HCl

130964-39-5 98+%

History

CL1876A

SB-408124 Hydrochloride

1431697-90-3 98+%

Chemical safety data sheet(MSDS)