Fedratinib | TG-101348

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Product Overview

Product Name	Fedratinib \| TG-101348 \| SAR 302503
CAS	936091-26-8
Formula	C27H36N6O3S
MW	524.68
Appearance	White to light yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Fedratinib, also known as TG101348 and SAR302503, is a JAK2 inhibitor, is also an orally bioavailable, small-molecule, ATP-competitive inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor TG101348 competes with JAK2 as well as the mutated form AK2V617F for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and the induction of tumor cell apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders (MPDs); the mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.

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History

CL1888

Fedratinib | TG-101348 | SAR 302503

936091-26-8 98+%

Fedratinib | TG-101348 | SAR 302503

Chemical safety data sheet(MSDS)