Home > Category > Signaling Pathways > Angiogenesis > VEGFR > Vatalanib Dihydrochloride; Vatalanib 2HCl

Vatalanib Dihydrochloride; Vatalanib 2HCl

ChemLeader 98+%

Catalog No：CL1906 CAS No.：212141-51-0 MDLNo： Formula：C20H17Cl3N4 MW：419.73

Collect Share

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
20 mg	In-stock	$116.00	Visible after login	- +
50 mg	In-stock	$216.00	Visible after login	- +
100 mg	In-stock	$366.00	Visible after login	- +

Chemical safety data sheet(MSDS)

Download MSDS

Certificate Of Authenticity(CPA)

Download COA

Inquiry Add To Cart

Product Overview
Related documents
Product details
Related literature

Product Overview

Product Name	Vatalanib Dihydrochloride; Vatalanib 2HCl
CAS	212141-51-0
Formula	C20H17Cl3N4
MW	419.73
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Vatalanib (PTK787 or ZK-222584, cpg-79787 2HCl) 2HCl is a novel, potent and orally bioavailable inhibitor of VEGFR2/KDR with potential anticancer activity. In a cell-free experiment, it inhibits VEGFR2/KDR with an IC50 of 37 nM, is less effective against VEGFR1/Flt-1, and is 18-fold more potent against VEGFR3/Flt-4. With strong anti-proliferative activity in vitro and strong antitumor efficaciousness in vivo, it is an anilinophthalazine analog. The protein kinase domains of VEGFR 1 and 2 are bound by vatalanib, which then inhibits them. The PDGF receptor, c-Kit, and c-Fms are among the related receptor tyrosine kinases that this agent binds to and inhibits.

Related literature

Sorry, there is no relevant literature

Sorry, no related items

History

CL1906

Vatalanib Dihydrochloride; Vatalanib 2HCl

212141-51-0 98+%