Product Name | Tanespimycin (17-AAG); KOS-953; KOS 953 |
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CAS | 75747-14-7 |
Formula | C31H43N3O8 |
MW | 585.69 |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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Product Name | Tanespimycin (17-AAG); KOS-953; KOS 953 |
---|---|
CAS | 75747-14-7 |
Formula | C31H43N3O8 |
MW | 585.69 |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy.