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MCC950 Sodium (CP-456773 Sodium)

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Catalog No：CL1969 CAS No.：256373-96-3 MDLNo： Formula：C20H23N2NaO5S MW：426.46

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$200.00	Visible after login	- +
10 mg	In-stock	$280.00	Visible after login	- +
25 mg	In-stock	$460.00	Visible after login	- +
50 mg	In-stock	$820.00	Visible after login	- +

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Product Overview

Product Name	MCC950 Sodium (CP-456773 Sodium)
CAS	256373-96-3
Formula	C20H23N2NaO5S
MW	426.46
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

MCC950 is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation. It inhibits ATP-induced IL-1β release in LPS-primed mouse bone marrow-derived macrophages (BMDMs; IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM, indicating inhibition of both canonical and non-canonical NLRP3 inflammasome activation, respectively. MCC950 is selective for NLRP3 over NLRC4 and absent in melanoma 2 (AIM2) inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM. It reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages when used at a concentration of 1 µM. MCC950 (10 mg/kg) reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation. It improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at the same dose.

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CL1969

MCC950 Sodium (CP-456773 Sodium)

256373-96-3 98+%