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Gemcitabine Hydrochloride; Gemcitabine HCl

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Catalog No：CL1996A CAS No.：122111-03-9 MDLNo： Formula：C₉H₁₂ClF₂N₃O₄ MW：299.66

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
250 mg	In-stock	$260.00	Visible after login	- +
500 mg	In-stock	$400.00	Visible after login	- +
1 g	In-stock	$750.00	Visible after login	- +
5 g	In-stock	$3100.00	Visible after login	- +

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Product Overview

Product Name	Gemcitabine Hydrochloride; Gemcitabine HCl
CAS	122111-03-9
Formula	C₉H₁₂ClF₂N₃O₄
MW	299.66
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma. Formulations containing gemcitabine have been used in the treatment of cancer.

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CL1996A

Gemcitabine Hydrochloride; Gemcitabine HCl

122111-03-9 98+%