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Panobinostat

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Catalog No：CL2002 CAS No.：404950-80-7 MDLNo： Formula：C21H23N3O2 MW：349.43

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	$220.00	Visible after login	- +
20 mg	In-stock	$320.00	Visible after login	- +
100 mg	In-stock	$900.00	Visible after login	- +

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Product Overview

Product Name	Panobinostat
CAS	404950-80-7
Formula	C21H23N3O2
MW	349.43
Appearance	Light brown powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. On 2/23/2015, it received FDA accelerated approval for use in patients with multiple myeloma who had received at least 2 previous treatments, including bortezomib and an immunomodulatory agent.

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CL2002

Panobinostat

404950-80-7 98+%