Product Name | ABT-494(Upadacitinib) Free base |
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CAS | 1310726-60-3 |
Formula | C₁₇H₁₉F₃N₆O |
MW | 380.37 |
Appearance | White to yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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Product Name | ABT-494(Upadacitinib) Free base |
---|---|
CAS | 1310726-60-3 |
Formula | C₁₇H₁₉F₃N₆O |
MW | 380.37 |
Appearance | White to yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.