Everolimus | RAD-001 | 依维莫司

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Availability

Price(USD)

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Quantity

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Product Overview

Product Name	Everolimus \| RAD-001
CAS	159351-69-6
Formula	C53H83NO14
MW	958.22
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.

Related literature

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes,Limitations, and Further Proposals.

PMID: 20360931 PMCID: PMC2847314 DOI: 10.1593/tlo.09277

mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor.

PMID: 19223496 DOI: 10.1158/1078-0432.CCR-08-2057

Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia.

PMID: 29077243 PMCID: PMC5765289 DOI: 10.1111/cas.13431

Sorry, no related items

History

CL2331

Everolimus | RAD-001

159351-69-6 98+%

Everolimus | RAD-001

Chemical safety data sheet(MSDS)