SRT 1720 monohydrochloride

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	SRT 1720 monohydrochloride
CAS	2060259-60-9
Formula	C25H23N7OS ·HCl
MW	506.02 \| 469.57(free)
Appearance	Brown to reddish brown
Storage condition	4°C, stored under nitrogen

Product details

SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

Related literature

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Nature. 2007 Nov 29;450(7170):712-6

re sirtuins viable targets for improving healthspan and lifespan?

PMID: 22653216 PMCID: PMC4684642 DOI: 10.1038/nrd3738

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

PMID: 22546858 PMCID: PMC3366403 DOI: 10.1172/JCI60132

Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.

PMID: 25411356 PMCID: PMC4297239 DOI: 10.1158/1535-7163.MCT-14-0584