H-89

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	H-89
CAS	127243-85-0
Formula	C20 H20 Br N3 O2 S
MW	446.36
Appearance	Off-white to light brown powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC₅₀ of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.

Related literature

Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres.

PMID: 11763200 DOI: 10.1023/a:1012289526618

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

PMID: 2156866

Effects of BL-191 and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice.

PMID: 21946102 DOI: 10.1016/j.ejphar.2011.09.026

CL2397A

H-89 Dihydrochloride | H 89 2HCl

History

Chemical safety data sheet(MSDS)