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Eltrombopag | Eltrombopag Free Base

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Catalog No:CL2444 CAS No.:496775-61-2 MDLNo: Formula:C25H22N4O4 MW:442.47
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25 mg In-stock $220.00 Visible after login
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50 mg In-stock $352.00 Visible after login
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Product Overview
Product Name Eltrombopag | Eltrombopag Free Base
CAS496775-61-2
FormulaC25H22N4O4
MW442.47
AppearanceYellow to orange powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Eltrombopag (formerly SB-497115; SB 497115; SB497115; trade name PROMACTA), a member of the biarylhydrazone class, is a novel nonpeptide agonist of the thrombopoietin receptor (TpoR) approved for use in the treatment of chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP). Eltrombopag demonstrates an EC50 of 0.27 μM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR. Eltrombopag activates the receptor by association with metal ions (i.e., Zn2+) and specific amino acids within the transmembrane and juxtamembrane domains of the TpoR.

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