Product Name | Torin 2 |
---|---|
CAS | 1223001-51-1 |
Formula | C24H15F3N4O |
MW | 432.40 |
Appearance | White to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
5 mg | 3-5days | $150.00 | Visible after login | |
10 mg | 3-5days | $225.00 | Visible after login | |
25 mg | 3-5days | $415.00 | Visible after login |
Product Name | Torin 2 |
---|---|
CAS | 1223001-51-1 |
Formula | C24H15F3N4O |
MW | 432.40 |
Appearance | White to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for mTOR with a superior pharmacokinetic profile to previous inhibitors ((EC50 = 0.3 nM). It has been shown that Torin-2 displayed dramatic antiproliferative activity across a panel of cancer cell lines. Torin-2 showed a powerful cytotoxic activity, inhibiting the growth of each cell line in a dose-dependent manner, with an IC₅₀ in the nanomolar range. Torin-2 caused both apoptosis and autophagy, induced cell cycle arrest in G₀/G₁ phase and affected both mTORC1 and mTORC2 activities.