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Torin 2

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Catalog No:CL2496 CAS No.:1223001-51-1 MDLNo: Formula:C24H15F3N4O MW:432.40
Size Availability Price(USD) VIP Price (USD) Quantity
5 mg 3-5days $150.00 Visible after login
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10 mg 3-5days $225.00 Visible after login
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25 mg 3-5days $415.00 Visible after login
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Product Overview
Product Name Torin 2
CAS1223001-51-1
FormulaC24H15F3N4O
MW432.40
AppearanceWhite to light yellow powder
Storage condition Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for mTOR with a superior pharmacokinetic profile to previous inhibitors ((EC50 = 0.3 nM). It has been shown that Torin-2 displayed dramatic antiproliferative activity across a panel of cancer cell lines. Torin-2 showed a powerful cytotoxic activity, inhibiting the growth of each cell line in a dose-dependent manner, with an IC₅₀ in the nanomolar range. Torin-2 caused both apoptosis and autophagy, induced cell cycle arrest in G₀/G₁ phase and affected both mTORC1 and mTORC2 activities.

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