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Evofosfamide (TH-302)

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Catalog No：CL2636 CAS No.：918633-87-1 MDLNo： Formula：C9H16Br2N5O4P MW：449.04

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Product Overview

Product Name	Evofosfamide (TH-302)
CAS	918633-87-1
Formula	C9H16Br2N5O4P
MW	449.04
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Evofosfamide (TH-302) is potent and selective that has an IC50 of 19 nM. It exhibits 270-fold increased cytotoxicity under hypoxia compared to their potency under aerobic conditions and is stable to cytochrome P450 metabolism. Under hypoxia, TH-302 is selectively potent and liver microsomes tolerate it well. With a high hypoxic selectivity [Hypoxia cytotoxicity ratio (HCR) = 270], replacing the chlorine with bromine in the phosphorus mustard in 3b results in a 10-fold increase in potency. Under N2, TH-302 exhibits strong cytotoxicity against human lung cancer H460 cells and human colon cancer HT29 cells. With an IC90 of 0.1 μM and 0.2 μM, respectively, TH-302 inhibits HT29 cells and H460 cells.

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CL2636

Evofosfamide (TH-302)

918633-87-1 98+%