Tesirine(SG3249)

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$5266.00	Visible after login	- +
5 mg	3-5days	$11590.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$5266.00

Visible after login

- +

5 mg

3-5days

$11590.00

Visible after login

- +

Product Overview

Product Name	Tesirine \| SG3249
CAS	1595275-62-9
Formula	C75H101N9O23
MW	1496.65
Appearance	White to light yellow powder
Storage condition	Avoid light, nitrogen, -20 ℃

Product details

Tesirine (SG-3249; SG3249), cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer used as an antibody-drug conjugate (ADC) payload; Tesirine was designed to combine the potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. Rovalpituzumab tesirine is a first-in-class ADC directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.

Related literature

Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload.

PMID: 27882195 PMCID: PMC5108040 DOI: 10.1021/acsmedchemlett.6b00062

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.

PMID: 29992976 PMCID: PMC6041317 DOI: 10.1038/s41598-018-28533-4

Sorry, no related items

History

CL2658

Tesirine | SG3249

1595275-62-9 95+%

Tesirine | SG3249

Chemical safety data sheet(MSDS)