MK-0752

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$148.00	Visible after login	- +
5 mg	3-5days	$368.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$148.00

Visible after login

- +

5 mg

3-5days

$368.00

Visible after login

- +

Product Overview

Product Name	MK-0752
CAS	471905-41-6
Formula	C21H21ClF2O4S
MW	442.91

Product details

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC₅₀ of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

Related literature

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

PMID: 20463236 PMCID: PMC2913973 DOI: 10.1523/JNEUROSCI.1381-10.2010

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

PMID: 20068161 PMCID: PMC3442245 DOI: 10.1158/0008-5472.CAN-09-1681

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.

PMID: 22547604 DOI: 10.1200/JCO.2011.39.1540

Sorry, no related items

History

CL2924

MK-0752

471905-41-6 98+%

Chemical safety data sheet(MSDS)