Ruxolitinib | INCB018424 | Ruxolitinib Free base | 鲁索替尼 | 鲁索利替尼 | 芦可替尼

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Price(USD)

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Quantity

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Product Overview

Product Name	Ruxolitinib \| INCB018424 \| Ruxolitinib Free base \| (R)-Ruxolitinib
CAS	941678-49-5
Formula	C17H18N6
MW	306.37
Appearance	White to light yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Related literature

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

PMID: 20130243 PMCID: PMC3953826 DOI: 10.1182/blood-2009-04-214957

Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.

PMID: 27379204 PMCID: PMC4904019 DOI: 10.3389/fonc.2016.00142

Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model.

PMID: 29515770 PMCID: PMC5839401 DOI: 10.18632/oncotarget.24267

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History

CL2956

Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib

941678-49-5 98+%

Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib

Chemical safety data sheet(MSDS)