Recombinant Human Interleukin 8 (rHulL-8

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25 µg	In-stock	$400.00	Visible after login	- +

Product Overview

Product Name	Recombinant Human Interleukin 8 (rHulL-8)
MW	Approximately 8.3kD.
Storage condition	Lyophilized samples are stable for 36 months from date of manufacture at -20℃ to -70℃. Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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Product details

Recombinant human interleukin-8 is recombinantly expressed in yeast and contains 72 amino acids without glycosylation sites.

Interleukin-8 (IL-8), also known as CXCL8, GCP-1, and NAP-1, is a widely expressed proinflammatory member of the CXC family of chemokines. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). IL-8/CXCL8 can associate into a homodimer or a heterodimer with CXCL4/PF4 (2), and it can interact with matrix and cell surface glycosaminoglycans. Near its N-terminus, this 8-9 kDa chemokine contains an ELR motif which is important for its angiogenic properties. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. In addition, IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. It induces VEGF expression, vascular endothelial cell proliferation, angiogenesis, and tumor cell invasiveness.

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History

CLRP1019

Recombinant Human Interleukin 8 (rHulL-8)

N/A 97%

Recombinant Human Interleukin 8 (rHulL-8)

Chemical safety data sheet(MSDS)