Recombinant Human Interleukin 12 (rHulL-12)

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100 µg	In-stock	$1136.00	Visible after login	- +

Product Overview

Product Name	Recombinant Human Interleukin 12 (rHulL-12)
Storage condition	Lyophilized samples are stable for 36 months from date of manufacture at -20℃ to -70℃. Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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Product details

Interleukin-12 (IL-12), also known as IL-12p70, cytotoxic lymphocyte maturation factor (CLMF) and natural killer cell stimulatory factor (NKSF), is primarily produced by dendritic cells and macrophages in response to bacterial pathogens [1,2]. It promotes Th1 responses and is a powerful inducer of interferon gamma (IFN-γ). IL-12 is a heterodimeric 70 kDa cytokine composed of two subunits, p35 and p40.

Recombinant human IL-12 is produced in Chinese hamster ovary (CHO) cells transfected with a fusion gene encoding the p35 and p40 subunits linked by a decapeptide containing two elastin motifs. These transfected cells produce and secrete biologically active IL-12. The recombinant protein is purified by size exclusion chromatography.

References:

1. Vignali DA. & Kuchroo VK., 2012. IL-12 family cytokines: immunological playmakers. Nat Immunol. 13(8):722-8.
2. Trinchieri G.,1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 13:251-76.

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History

CLRP1020

Recombinant Human Interleukin 12 (rHulL-12)

N/A 97%

Recombinant Human Interleukin 12 (rHulL-12)

Chemical safety data sheet(MSDS)