Product Name | Theaflavin-3,3'-digallate | TF-3 | ZP10 | TFBG |
---|---|
CAS | 33377-72-9 |
Formula | C43H32O20 |
MW | 868.70 |
Appearance | Brown to red powder |
Storage condition | -20°C, sealed storage, away from moisture and light |
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Product Name | Theaflavin-3,3'-digallate | TF-3 | ZP10 | TFBG |
---|---|
CAS | 33377-72-9 |
Formula | C43H32O20 |
MW | 868.70 |
Appearance | Brown to red powder |
Storage condition | -20°C, sealed storage, away from moisture and light |
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1. Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent.
Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor.
PMID: 33192499 PMCID: PMC7609463 DOI: 10.3389/fphar.2020.514313
Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line.
PMID: 29200992 PMCID: PMC5700489 DOI: 10.1080/16546628.2017.1400340