LY294002 | NSC 697286 | SF 1101

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	$86.00	Visible after login	- +
10 mg	3-5days	$126.00	Visible after login	- +
25 mg	3-5days	$166.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

3-5days

$86.00

Visible after login

- +

10 mg

3-5days

$126.00

Visible after login

- +

25 mg

3-5days

$166.00

Visible after login

- +

Product Overview

Product Name	LY294002 \| NSC 697286 \| SF 1101
CAS	154447-36-6
Formula	C19H17NO3
MW	307.34
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

LY294002, a morpholine-containing compound designed based on the flavonoid quercetin, is a potent and cell-permeable PI3K inhibitor, inhibiting PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively. Additionally, it inhibits BET (for example, BRD2, BRD3, and BRD4). It is more stable in solutions than the PI3K inhibitor Wortmannin. By acting on the ATP binding site of the catalytic subunit of PI3K, LY294002 is selective against p110α, p110β, p110γ and p110δ.

Related literature

Exploring the specificity of the PI3K family inhibitor LY294002.

Biochem J. 2007 May 15;404(1):15-21.

Evidence for functional redundancy of class IA PI3K isoforms.

PMID: 17362206 PMCID: PMC1896275 DOI: 10.1042/BJ20070003

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

PMID: 23386830 PMCID: PMC3560216 DOI: 10.3389/fphar.2013.00005

LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats.

PMID: 30456785 DOI: 10.1111/and.13196