Vonoprazan | TAK-438 free base | 沃诺拉赞| 881681-00-1

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Vonoprazan \| TAK-438 free base
CAS	881681-00-1
Formula	C17H16FN3O2S
MW	345.39
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H⁺,K⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori.

Related literature

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).

PMID: 22512618 DOI: 10.1021/jm300318t

CL1412

Vonoprazan Fumarate | TAK-438

881681-01-2 98+%

History

CL1412A

Vonoprazan | TAK-438 free base

881681-00-1 98+%

Vonoprazan | TAK-438 free base

Chemical safety data sheet(MSDS)