SB408124

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	SB408124
CAS	288150-92-5
Formula	C19H18F2N4O
MW	356.37
Appearance	White to off-white powder

Product details

SB-408124 is a elective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states.

Related literature

A major role for perifornical orexin neurons in the control of glucose metabolism in rats.

PMID: 19592616 PMCID: PMC2731521 DOI: 10.2337/db09-0385

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.

PMID: 14691055 PMCID: PMC1574197 DOI: 10.1038/sj.bjp.0705610

The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats.

PMID: 22350729 DOI: 10.1007/s00424-012-1080-4

Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.

PMID: 21857082 DOI: 10.1016/s1734-1140(11)70583-7

CL1876A

SB-408124 Hydrochloride

History

Chemical safety data sheet(MSDS)