SB-743921

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	SB-743921
CAS	940929-33-9
Formula	C31H34Cl2N2O3
MW	553.52
Appearance	Off-white to yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

SB743921 is a kinesin spindle protein (KSP) inhibitor with K_i of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

Related literature

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer.

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.

PMID: 25146433 DOI: 10.3109/10428194.2014.956319

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

J Med Chem. 2013 Mar 14;56(5):1878-93.

History

Chemical safety data sheet(MSDS)