SB-743921 free base

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	SB-743921 free base
CAS	618430-39-0
Formula	C31H33ClN2O3
MW	517.06

Product details

SB-743921 (SB-921) is an inhibitor of Kinesin Spindle Protein (KSP), a mitotic protein essential for cell cycle control and motility. It functions by selectively targeting rapidly dividing cells and disrupting spindle formation during cell division, leading to G2/M phase arrest and ultimately causing cell death. It also inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cell lines.

Related literature

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer.

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.

PMID: 25146433 DOI: 10.3109/10428194.2014.956319

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

PMID: 23394180 PMCID: PMC3759169 DOI: 10.1021/jm3014597

History

Chemical safety data sheet(MSDS)