Product Name | Laduviglusib monohydrochloride | CHIR-99021 Monohydrochloride | T99021 Monohydrochloride |
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CAS | 1797989-42-4 |
Formula | C22H18Cl2N8·HCl |
MW | 501.80 |
Appearance | White to yellow powder |
Storage condition | 4°C, sealed storage, away from moisture |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
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Product Name | Laduviglusib monohydrochloride | CHIR-99021 Monohydrochloride | T99021 Monohydrochloride |
---|---|
CAS | 1797989-42-4 |
Formula | C22H18Cl2N8·HCl |
MW | 501.80 |
Appearance | White to yellow powder |
Storage condition | 4°C, sealed storage, away from moisture |
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.