Product Name | Laduviglusib dihydrochloride | CHIR-99021 dihydrochloride | CT99021 dihydrochloride |
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CAS | 2109414-84-6 |
Formula | C22H18Cl2N8·2HCl |
MW | 538.26 |
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Product Name | Laduviglusib dihydrochloride | CHIR-99021 dihydrochloride | CT99021 dihydrochloride |
---|---|
CAS | 2109414-84-6 |
Formula | C22H18Cl2N8·2HCl |
MW | 538.26 |
Laduviglusib (CHIR-99021) dihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.