Product Name | Ruxolitinib sulfate | INCB018424 sulfate |
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CAS | 1092939-16-6 |
Formula | C17H18N6 · H2SO4 |
MW | 404.44 | 306.37(free) |
Appearance | Off-white to gray powder |
Storage condition | 4°C, sealed storage, away from moisture |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
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Product Name | Ruxolitinib sulfate | INCB018424 sulfate |
---|---|
CAS | 1092939-16-6 |
Formula | C17H18N6 · H2SO4 |
MW | 404.44 | 306.37(free) |
Appearance | Off-white to gray powder |
Storage condition | 4°C, sealed storage, away from moisture |
Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
PMID: 20130243 PMCID: PMC3953826 DOI: 10.1182/blood-2009-04-214957
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis.
PMID: 22375970 DOI: 10.1056/NEJMoa1110556
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis.
PMID: 22375970 DOI: 10.1056/NEJMoa1110556